Augenärztin, Forschung, Wissenschaftliche Arbeit Augen

Wissenschaftliche Arbeiten und Forschung Dr. Falkner-Radler

Meine wissenschaftliche Tätigkeit mit dem Schwerpunkt hinterer Augenabschnitt (Netzhaut und Makula) begannen bereist während meiner Ausbildung an der Krankenanstalt Rudolfstiftung.

Neben Arbeiten zu den bis dato etablierten Operationsverfahren zur Behandlung von Netzhautabhebungen (Buckelchirurgie, Primäre Vitrektomie und Silikonölchirurgie) habe ich unterschiedliche Operationsverfahren bei Endstadien der altersbedingten Makuladegeneration (AMD) erforscht: Submakuläre ChirurgieTransplantation von Pigmentepithelzellen (Suspension) und Pigmentepithelteilen (Flap) der Netzhaut. Siehe dazu auch den Buchtipp und das Interview: „Das alternde Auge”.

Es folgten Forschungen zu neuesten Untersuchungsmethoden, der Optischen Kohärenztomographie (OCT), die eine äußerst detailgetreue Darstellung der einzelnen Schichten und Veränderungen der Netzhautmitte (Makula) erlaubt und somit unverzichtbar bei der Diagnosestellung der altersbedingten Makuladegeneration (AMD), von epiretinalen Membranen (siehe auch: Verweis 2) und Makulaforamen wurde.

Zusätzlich wurden Studien über Operationsergebnisse dieser Patienten durchgeführt und über viel versprechende Ergebnisse nach kombinierter Chirurgie (Kataraktoperation kombiniert mit Vitrektomie, siehe auch Verweis 2), auch unter Verwendung neuester Technologien, berichtet.

Die Verleihung der Lehrbefugnis für Augenheilkunde und Optometrie als Privatdozentin erfolgte auf der Grundlage meiner Habilitationsschrift über „Neueste Erkenntnisse in der Behandlung der Netzhautabhebung und der Makulachirurgie“ und meiner zahlreichen wissenschaftlichen Arbeiten. Aufgrund meiner Forschung und Erfahrung bin ich zum Adjunct Associate Professor of Clinical Ophthamology der Cornell University berufen worden.

Erstautorschaften:

Falkner-Radler C.I., Glittenberg C, Gabriel M, Binder S. Intrasurgical Micropscope-Integrated Spectral-Domain Optical Coherence Tomography assisted Membrane Peeling. Retina 2015;35(10):2100-6.

Falkner-Radler C.I., Graf A, Binder S. Vitrectomy combined with endolaser or an encircling scleral buckle in primary retinal detachment surgery: a pilot study. Acta Ophthalmol. 2015; 93(5):464-9.

Falkner-Radler C.I., Gabriel M., Binder S. Spontaneous closure of an idiopathic macular hole 9 months after unsuccessful vitreoretinal surgery. Retinal Cases & Brief Reports 2014;8(3):157-60.

Falkner-Radler CI, Smretschnig E, Graf A, Binder S. Outcome after silicone oil Removal and simultaneous 360° endolaser treatment. Acta Ophthalmol. 2011; 89(1):e46-51.

Falkner-Radler CI, Myung JS, Moussa S, Chan RVP, Smretschnig E, Kiss S, Graf A, D’Amico DJ, Binder S. Trends in Primary Retinal Detachment Surgery: Results of a Bicenter Study. Retina 2011; 31(5):928-36.

Falkner-Radler CI, Krebs I, Glittenberg C, Povazay B, Drexler W, Graf A, Binder S. Human retinal pigment epithelium (RPE) transplantation: outcome after autologous RPE-choroid sheet and RPE cell-suspension in a randomised clinical study. Br J Ophthalmol 2010; 95(3):370-5.

Falkner-Radler CI, Glittenberg C, Hagen S, Benesch T, Binder S. Spectral-Domain Optical Coherence Tomography for Monitoring Epiretinal Membrane Surgery; Ophthalmology 2010; 117(4): 789-805.

Falkner-Radler CI, Benesch T, Binder S. Accuracy of Preoperative Biometry in Vitrectomy Combined with Cataract Surgery for Patients with Epiretinal Membranes and Macular Holes: Results of a Prospective Controlled Clinical Trial. J Cataract Refract Surg 2008; 34(10):1754-1760.

Falkner-Radler CI, Binder S. Langzeitresultate nach mikrochirurgischer skleraeindellender Ablatiochirurgie, Klinisches Monatsblatt für Augenheilkunde 2008; 225(12):1055-1061.

Falkner-Radler CI, Glittenberg C, Binder S. Spectral Domain High-definition Optical Coherence Tomography in Patients Undergoing Epiretinal Membrane Surgery. Ophthalmic Surgery, Lasers and Imaging 2008; 29:S50-S56.

Falkner-Radler CI, Benesch T, Binder S. Blue light-Filter intraocular lenses in vitrectomy combined with cataract surgery: Results of a randomized controlled clinical trial. Am J Ophthalmol 2008; 145(3):499-503.

Falkner CI, Leitich H, Frommlet F; Bauer P, Binder S. The end of submacular surgery for age related macular degeneration: A meta–analysis. Graefe’s Archive for Clinical and Experimental Ophthalmology 2007; 245(4): 490-501.

Falkner CI, Binder S, Leitich H: Systematischer Review der submakulären Chirurgie bei altersabhängiger Makuladegeneration (AMD). Spektrum der Augenheilkunde 2003;17/1:15-20.

Falkner CI, Binder S, Kruger A. Outcome after silicone oil removal. Br J Ophthalmol 2001;85(11):1324-1327.

Falkner CI, Binder S, Kruger A. Resultate nach Silikonölentfernung bei PVR-Fällen. Spektrum der Augenheilkunde 2001;15/3:101-106.

Falkner CI, Binder S. Mikrochirurgisch versorgte Netzhautablösungen. Spektrum der Augenheilkunde 2001;15/6:233-237.

Koautorschaften:

Smretschnig E, Falkner-Radler CI, Spörl J, Kivaranovic D, Binder S, Krepler K. Primary Retinal Detachment Surgery: Changes in Treatment and Outcome in an Austrian Tertiary Eye Center, Ophthalmologica 2017 [Epub ahead of print]

Lytvynchuk LM, Glittenberg CG, Falkner-Radler CI et al. Evaluation of intraocular lens position during phacoemulsification using intraoperative spectral-domain optical coherence tomography. J Cataract Refract Surg. 2016;42(5):694-702.

Haas P, Falkner-Radler CI, Wimpissinger B, Zebrowska M, Binder S. Needle Size in intravitreal injections- pain evaluation of a randomized clinical. trial. Acta Ophthalmol 2016;94(2):198-202.

Smretschnig S,  Falkner-Radler CI, Binder S, Spörl J, Ristl R, Glittenberg C,  Krepler K. Vision-related Quality of Life and Visual Function after Retinal Detachment Surgery, Retina 2016;36(5):967-73.

Gabriel M, Falkner-Radler CI und  Binder S. Subretinal migration of Membrane Blue-Dual during epiretinal membrane peeling. Spektrum Augenheilkunde 2015;29,(4):156-158.

Lee S, Falkner-Radler CI und Binder S. The course of lamellar macular holes: assessment by Cirrus and Stratus OCT. Spektrum der Augenheilkunde, 2014, 28: 142

Brunner S, Mora A, Fonseca J, Weber T, Falkner-Radler CI, Oeser R, Binder S. Monitoring of Drusen and Geographic Atrophy Area Size after Cataract Surgery Using the MD3RI Tool for Computer-Aided Contour Drawing. Ophthalmologica 2013; 229 (7):86-93.

Binder S, Falkner-Radler CI; Hauger C, Matz H, Glittenberg C. „Feasibility of intrasurgical spectral-domain-optical coherence tomography. Retina 2011; 31(7):1332-6.

Hagen S, Krebs I, Haas P, Glittenberg C, Falkner-Radler CI, Graf A, Ansari Shahrezaei S, Binder S. Reproducibility and comparison of retinal thickness and volume measurements in normal eyes determined with two different Cirrus OCT scanning protocols. Retina 2011;31(1):41-47.

Glittenberg C, Krebs I, Falkner-Radler C, Zeiler F, Haas P, Hagen S, Binder S. Advantages of using a ray-traced, three-dimensional rendering system for spectral domain Cirrus HD-OCT to visualize subtle structures of the vitreoretinal interface. Ophthalmic Surg Lasers Imaging. 2009;40:127-34.

Krebs I, Falkner-Radler C; Hagen S; Haas P; Brannath W; Lie S; Ansari-Shahrezaei S; Binder S. Qualitiy of Threshold Algorithm in Age-related Macular Degeneration: Stratus versus Cirrus OCT; Invest Ophthalmol Vis Sci 2009; 50(3):995-1000.

Glittenberg C, Krebs I, Falkner-Radler C, Zeiler F, Haas P, Hagen S, Binder S. Advantages of Using a Ray-traced, Three-dimensional Rendering System for Spectral Domain Cirrus HD-OCT to Visualize Subtle Structures of the Vitreoretinal Interface. Ophthalmic Surgery, Lasers and Imaging 2008; 39:S21-S29.

Povazay B, Hermann B, Unterhuber A, Hofer B, Sattmann H, Zeiler F,Morgan JE, Falkner-Radler C, Glittenberg C, Blinder S, Drexler W. Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: Enhanced performance and choroidal penetration in cataract patients. J Biomed Opt 2007;12(4):041211.

C. Glittenberg, B. Povaczay, B. Hermann, F. Zeiler, C. Falkner, W. Drexler, S. Binder. Dreidimensionale Rekonstruktion von Schichtbildaufnahmen der Netzhaut. Spektrum Augenheilkd 2007; 21:13-16.

Buchbeiträge:

Susanne Binder and Christiane Falkner-Radler: Chapter XII: Age related changes in the Macula Lutea: I Types and future directions, Christiane Falkner-Radler and Susanne Binder. Chapter XIII: Age related changes in the Macula Lutea: II Idiopathic Macular Holes, Christiane Falkner-Radler and Susanne Binder. Chapter XIV: Age related changes in the Macula Lutea: Epiretinal Membranes; Age-Related Changes of the Human Eye, Series: Aging Medicine by Carlo Cavallotti, Springer Verlag 2008

Falkner CI, Binder S, Leitich H. Submacular Surgery for Age – Related Macular Degeneration: A Systematic Review; The Macula- Diagnosis, Treatment and Future Trends by Binder S, Springer Verlag, 2004

Binder S, Glittenberg C, Falkner-Radler C, Krebs I. Influence of vitreous Traction on AMD. Anomalous posterior vitreous detachment is associated with dry AMD, and vitreomacular attachment with wet AMD. Retina Today 2009.

Interview:

„Das alternde Auge” (“The Aging Eye“) – an interview with Christiane I. Falkner-Radler, M.D. by Inge Smolek, Spektrum der Augenheilkunde 2008 22/6: 393–395.

Abstracts:

Smretschnig S, Krepler K, Falkner-Radler CI, Spörl J, Binder S. Surgery for primary rhegmatogenous retinal detachment- Anatomical and visual outcome. Invest Ophthalmol Vis Sci 2014; 55:1086.

Falkner-Radler CI, Binder S. Refractive Outcome after Combined Microincision Cataract Surgery and 23-Gauge Vitrectomy. Invest Ophthalmol Vis Sci 2014; 55:2344.

Bukaty E, Falkner-Radler CI, Smretschnig K, Krepler K, Spörl J, Binder S. Refractive Outcome after Combined Cataract Surgery and Vitrectomy in Patients with Retinal Detachments. ARVO Meeting Abstracts April 30, 2014 55:1116.

Falkner Radler CI, Cho M, Graf A, Orlin A, Chan RVP, Kiss S, D´Amico D, Binder S. Symptomatic Posterior Vitreous Detachment: The predictive value of the posterior hyaloid face and symptomatology Invest Ophthalmol Vis Sci 2013 54:2842

Falkner-Radler CI, Wimpissinger B, Glittenberg C; Graf A, Binder S. Needle Size in Intravitreal Injections-Preliminary Results of a Randomized Clinical Trial. Invest Ophthalmol Vis Sci 2012; 53: E-Abstract 884.

Glittenberg C, De Lamar P, Esmaeelpour M, Zeiler F, Falkner Radler CI, Binder S. The Use of Triamcinolone as a Contrast Agent for Intrasurgical OCT. Invest Ophthalmol Vis Sci 2012; 53: E-Abstract 2095

Lie S, Falkner Radler CI, Hochwarter A, Smretschnig E, Binder S. The Course of Lamellar Macular Holes assessed with Cirrus and Stratus OCT. Invest Ophthalmol Vis Sci 2012; 53: E-Abstract 5214

Falkner-Radler CI, Myung JS, Moussa S, Chan RVP, Smretschnig E, Kiss S,Graf A, D’Amico DJ, Binder S. Trends in Primary Rhegmatogenous Retinal Detachment Surgery Based on a Bicenter Study. Invest Ophthalmol Vis Sci 2011; 52: E-Abstract 6175.

S Binder, C. I. Falkner-Radler , C Hauger, H Matz, C Glittenberg.Clinical Applications of Intrasurgical SD-Optical Coherence Tomography. Invest Ophthalmol Vis Sci 2011; 52: E-Abstract 268.

S Binder, C Glittenberg, C Hauger, H Matz, CI Falkner-Radler. The value of an intrasurgical SD-Optical Coherence Tomography. Invest Ophthalmol Vis Sci 2011; 52: E-Abstract 1325.

C. I. Falkner-Radler, C. Glittenberg, S. Hagen, S. Binder. „Spectral-domain optical coherence tomography in epiretinal membrane surgery. Invest Ophthalmol Vis Sci 2010; 51: E-Abstract 2555.

S Binder, C. I. Falkner-Radler , C Hauger, H Matz, C Glittenberg.Clinical Applications of Intrasurgical SD-Optical Coherence Tomography. Invest Ophthalmol Vis Sci 2010; 52: E-Abstract 268.

C. I. Falkner-Radler and S. Binder. Primary Vitrectomy Combined With 360° Endolaser or Encircling Band for Rhegmatogenous Retinal Detachment (V.E.E. Study): Intermediate Results. Invest Ophthalmol Vis Sci 2009; 50: E-Abstract 2064.

S. Binder, C. Glittenberg, C. I. Falkner-Radler and I. Krebs. 3-D SD- OCT for Higher Precision in the Evaluation of Vitreoretinal Adhesions in Exudative AMD. Invest Ophthalmol Vis Sci 2009;50: E-Abstract 5245.

C. I. Falkner-Radler, C. Glittenberg, P. Haas, and S. Binder. Cirrus HD-OCT for Evaluation of Epiretinal Membranes. Invest Ophthalmol Vis Sci 2008; 49: E-Abstract 4685.

C. G. Glittenberg, C. Falkner, F. Zeiler, S. Hagen, H. Paulina, I. Krebs, and S. Binder. A Raytraced Three Dimensional Display System for Visualizing Subtle Structures of the Vitreo-Retinal Interface Using Data from the Cirrus-HD OCT. Invest Ophthalmol Vis Sci 2008; 49: E-Abstract 1836.

C. I. Falkner-Radler, C. Glittenberg, B. Povazay, W. Drexler, and S. Binder. Correlation of UHR OCT With Standard-Resolution OCT and Visual Outcome After Autologous RPE Transplantation in AMD. Invest Ophthalmol Vis Sci 2007; 48: E-Abstract 5083.

B. Povazay, B. Hermann, A. Unterhuber, H. Sattmann, F. Zeiler, J. E. Morgan, C. Falkner-Radler, C. Glittenberg, S. Binder, and W. Drexler. Three-Dimensional High Speed OCT at 1050 nm vs. 800 nm: Enhanced Penetration Into Choroidal Tissue and Through Cataracts. Invest Ophthalmol Vis Sci 2007; 48: E-Abstract 4264.

C. G. Glittenberg, B. Povazay, B. Hermann, Z. Florian, C. Falkner, S. Harald, W. Drexler, and S. Binder. A Quantitative Analysis System for UHR-OCT. Invest Ophthalmol Vis Sci 2007; 48: E-Abstract 2760.

S. Binder, C. I. Falkner-Radler, C. Glittenberg, B. Povazay, W. Drexler, and I. Krebs. Autologous Retinal Pigment Epithelium (RPE)-Choroid Sheet Transplantation versus Autologous RPE Cell-Suspension Transplantation in Patients with Age-Related Macular Degeneration (AMD) – Clinical Results. Invest. Ophthalmol Vis Sci 2007; 48: E-Abstract 6027.

S. Binder, I. Krebs, B.V. Stanzel, C. Glittenberg, Ch.I. Falkner. “RPE Repair and Regeneration“, Abstract Summary-Mini Symposia, ARVO 2007 Fort Lauderdale, Florida, USA.

C.I. Falkner and S. Binder. UV–Filter IOL versus Yellow Blue Light–Filter IOL in Combined Cataract Surgery With Vitrectomy: A Prospective Randomized Clinical Trial. Invest Ophthalmol Vis Sci 2006; 47: E-Abstract 1484.

C.I. Falkner, S. Binder, H. Leitich, F. Frommlet, and P. Bauer. Removal of Subfoveal Choroidal Neovascularization versus Macular Translocation for Age–Related Macular Degeneration: A Meta–Analysis. Invest Ophthalmol Vis Sci 2005; 46: E-Abstract 197.

Brunner, I. Krebs, U. Stolba, C.I. Falkner, S. Binder, and P. Bauer. Cataract Surgery in Nonexsudative Age–Related Macular –First Results of a Prospective, Randomized, Multicenter Trial (ECAM–1). Invest Ophthalmol Vis Sci 2005; 46: E-Abstract 195.